특허 출원 및 등록
1. 공개특허 10-2021-0077845, 소변의 알파-씨누클레인 중합체 측정에 의한 파킨슨병 진단 정보의 수집방법 및 그 키트
발표한 학술 논문
- 2019년
- Ho DH, Lee H, Son I, Seol W. G2019s LRRK2 promotes mitochondrial fission and increases TNFα-mediated neuroinflammation responses. Anim Cells Syst (Seoul). 2019 Mar 1;23(2):106-111.
- Ho DH, Seol W, Son I. Upregulation of the p53-p21 pathway by G2019S LRRK2 contributes to the cellular senescence and accumulation of α-synuclein. Cell Cycle. 2019 Feb;18(4):467-475.
- Seol W, Nam D, Son I. Rab GTPases as Physiological Substrates of LRRK2 Kinase. Exp Neurobiol. 2019 Apr;28(2):134-145.
- Ho DH, Nam D, Seo MK, Park SW, Son I, Seol W. Leucine-rich Repeat Kinase 2 (LRRK2) Phosphorylates Rab10 in Glia and Neurons. Biomedical Science Letters 2019, 25(2): 177~184
- 2018년
- Nam D, Kim H, Choi DJ, Bae Y, Lee BD, Son I, Seol W (2018) Characterization of Parkinson’s Disease-related Pathogenic TMEM230 Mutants, Animal Cells and Systems, 22:2, 140-147
- Kim H, Ho DH, Son I, Seol W (2018) Methyonyl-tRNA-Synthetase Is a Novel Interacting Protein of LRRK2. Journal of life science Vol. 28, 170~175
- Kim H, Son I & Seol W (2018) Effect of leucine-rich repeat kinase 2 (LRRK2) on protein synthesis. Animal Cells and Systems, 22:1, 15-21,
- Jang J, Jeong S, Lee SI, Seol W, Seo H, Son I, Ho DH (2018) Oxidized DJ-1 levels in urine samples as a putative biomarker for Parkinson’s disease. Parkinson’s disease
- Jang J, Oh H, Nam D, Seol W, Seo MK, Park SW, Kim HG, Seo H, Son I, Ho DH. Increase in anti-apoptotic molecules, nucleolin, and heat shock protein 70, against upregulated LRRK2 kinase activity. Anim Cells Syst (Seoul). 2018 Sep 12;22(5):273-280.
- Ho DH, Kim H, Nam D, Sim H, Kim J, Kim HG, Son I, Seol W. LRRK2 impairs autophagy by mediating phosphorylation of leucyl-tRNA synthetase. Cell Biochem Funct. 2018 Dec;36(8):431-442.
- Ho DH, Je AR, Lee H, Son I, Kweon HS, Kim HG, Seol W. LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation. Exp Neurobiol. 2018 Jun;27(3):171-180.
- 2017년
- Yoon JH, Mo JS, Kim MY, Ann EJ, Ahn JS, Jo EH, Lee HJ, Lee YC, Seol W, Yarmoluk SM, Gasser T, Kahle PJ, Liu GH, Belmonte JCI, Park HS. (2017) LRRK2 functions as a scaffolding kinase of ASK1-mediated neuronal cell death. Biochim Biophys Acta.;1864:2356-2368
- Han KA, Yoo L, Sung JY, Chung SA, Um JW, Kim H, Seol W, Chung KC. (2017) Leucine-Rich Repeat Kinase 2 (LRRK2) Stimulates IL-1β-Mediated Inflammatory Signaling through Phosphorylation of RCAN1. Front. Cell Neurosci. May 11;11:125. doi: 10.3389/fncel.2017.00125.
- Ho DH, Seol W, Son IH (2017) Phosphorylation of p53 by LRRK2 induces microglial tumor necrosis factor-α mediated neurotoxicity, BBRC 482, 1088-1094
- 2016년
- Ho DH, Jang J, Joe EH, Son I, Seo H, Seol W. G2385R and I2020T Mutations Increase LRRK2 GTPase Activity. Biomed Res Int. 2016;2016:7917128. doi: 10.1155/2016/7917128. Epub 2016 May 25. PMID: 27314038; PMCID: PMC4897664.
- Mani M, Lee UH, Yoon NA, Kim HJ, Ko MS, Seol W, Joe Y, Chung HT, Lee BJ, Moon CH, Cho WJ, Park JW. Developmentally regulated GTP-binding protein 2 coordinates Rab5 activity and transferrin recycling. Mol Biol Cell. 2016 Jan 15;27(2):334-48. doi: 10.1091/mbc.E15-08-0558. Epub 2015 Nov 18. PMID: 26582392; PMCID: PMC4713135.
- Park SW, Nhu le H, Cho HY, Seo MK, Lee CH, Ly NN, Choi CM, Lee BJ, Kim GM, Seol W, Lee JG, Kim YH. p11 mediates the BDNF-protective effects in dendritic outgrowth and spine formation in B27-deprived primary hippocampal cells. J Affect Disord. 2016 May 15;196:1-10. doi: 10.1016/j.jad.2016.02.010. Epub 2016 Feb 9. PMID: 26896741.
- 2015년
- Lim J, Kim HI, Bang Y, Seol W, Choi HS, Choi HJ. (2015) Hypoxia-inducible factor-1α upregulates tyrosine hydroxylase and dopamine transporter by nuclear receptor ERRγ in SH-SY5Y cells. Neuroreport. 26,380-386.
- Yun HJ, Kim H, Ga IH, Oh H, Ho DH, Kim J, Seo H, Son I, Seol W, (2015) An early endosome regulator, Rab5b, is an LRRK2 kinase substrate. J. Biochem. 15 Jan 19. pii: mvv005
- Mani M, Lee UH, Yoon NA, Kim HJ, Ko MS, Seol W, Joe Y, Chung HT, Lee BJ, Moon CH, Cho WJ, Park JW. (2015) Developmentally regulated GTP-binding protein 2 coordinates Rab5 activity and transferrin recycling. Mol Biol Cell. 2015 Nov 18. pii: mbc.E15-08-0558.
- Ho DH, Kim H, Kim J, Sim H, Ahn H, Kim J, Seo H, Chung KC, Park BJ, Son I, Seol W (2015) Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression, Molecular Brain. 8:54.
- 2014년
- Ho DH, Yi S, Seo H, Son I, and Seol W. (2014) Increased DJ-1 in Urine Exosome of Korean Males with Parkinson's Disease. BioMed Research International, Volume 2014, Article ID 704678
- Park SW, Lee JG, Seo MK, Cho HY, Lee CH, Lee JH, Lee BJ, Baek JH, Seol W, Kim YH. (2014) Effects of mood-stabilizing drugs on dendritic outgrowth and synaptic protein levels in primary hippocampal neurons. Bipolar Disorder. 2014 Oct13. doi: 10.1111/bdi.12262.
- 호동환, 서혜명, 손일홍, 설원기 (2014) 파킨슨병의 원인유전자와 연관된 자가포식현상. 대한신경과학회지, 32:137-144.
- Park SW, Lee JG, Seo MK, Lee CH, Cho HY, Lee BJ, Seol W, Kim YH. (2014) Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons. International Journal of Neuropsychopharmacology 17:1831–1846.
- Seo MK, Lee CH, Cho HY, Lee JG, Lee BJ, Kim JE, Seol W, Kim YH, Park SW. (2014) Effects of antidepressant drugs on synaptic protein levels and dendritic outgrowth in hippocampal neuronal cultures. Neuropharmacology 79: 222-233
- 2013년
- Park JM, Ho DH, YunHJ, Kim HJ, Lee CH, Park SW, Kim YH, Son I, Seol W (2013) Dexamethasone induces the expression of LRRK2 and a-synuclein, two genes that when mutated cause Parkinson’s disease in an autosomal dominant manner. (2013) BMB Reports, ISSN: 1976-6696
- Yun HJ, Park J, Ho DH, Kim H, Kim C-H, Oh H, Ga I, Seo H, Chang S, Son I, Seol W (2013) LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25 Exp. Mol. Med. 45, e36; doi:10.1038/emm.2013.68
- Chung JY, Park HR, Lee SJ, Lee SH, Kim JS, Jung YS, Hwang SH, Ha NC, Seol W, Lee J, Park BJ.(2013) Elevated TRAF2/6 expression in Parkinson’s disease is caused by the loss of Parkin E3 ligase activity. Lab Invest. 93(6):663-76
- Park SW, Lee CH, Cho HY, Seo MK, Lee JG, Lee BJ, Seol W, Kee BS, Kim YH. (2013) Effects of antipsychotic drugs on the expression of synaptic proteins and dendritic outgrowth in hippocampal neuronal cultures. Synapse 67(5):224-34
- 2012년
- Kim B, Yang MS, Choi D, Kim JH, Kim HS, Seol W, Choi S, Jou I, Kim EY, Joe E. (2012) Impaired Inflammatory Responses in Murine Lrrk2- Knockdown Brain Microglia. PLOS One 7: e34693 eISSN-1932-6203 SCI:4.092
- Yang HD, Ho DH, Seol W. (2012) Unstable Repeat Expansion in Neurodegenerative Dementias: Mechanisms of Disease. Dementia and Neurocognitive Disorders (대한치매학회지). 11: 1-12